Chunk #21 — Method — Genotyping and Imputation

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The interplay of genes and adolescent development in substance use disorders: leveraging findings from GWAS meta-analyses to test developmental hypotheses about nicotine consumption.

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analyses. Those twins with genotypes versus those without did not differ significantly on measures of nicotine use (CPD, days smoked per month, or DSM-IIIR nicotine dependence symptomatology) or alcohol use, with the exception that individuals with genotypes drank slightly more at age 24 (Cohen’s d = .22, p = .01).