The cytochrome P450, cell cycle control, and alcohol dehydrogenase candidate genes groups also exhibited nominally significant (0.01<Ppermuted<0.05) associations with smoking behaviors (Table 4). The cytochrome P450 results may have been driven by association between SNPs at CYP2B6 with EVNV, and CYP2A6 and SMKAGE (Table 3). These results are consistent with evidence for the relationship between CYP2A6 genetic variation and both nicotine metabolism [81], [82], [83] and smoking behavior [41], [84].
