While we focus on case-control studies, we note that some related work has been published for studies of quantitative traits using variance components models. Sham et al. [2000] derived similar results for the impact of LD, and Hill et al. [2008] showed that additive variation (analogous to multiplicative effects in case-control studies) will tend to dominate even when nonadditive effects exist and the impact of LD is discounted.
