Chunk #7 — THEORETICAL DERIVATIONS — LD MODEL

Source

Disease model distortion in association studies.

Embedded

yes

Text

Let A and B be a pair of biallelic SNPs and code the alleles at each as 0 and 1. In the situations that we examine, A will be a causal SNP and B will be a marker SNP. Let fA = Pr(A = 1) be the frequency of allele 1 in the population at SNP A, and define fB similarly for SNP B.