We report herein the first GWS results for CAD to our knowledge. The sample includes a large proportion (18%–36%, depending on race and cohort) of individuals with CAD from 2 ancestral populations in 3 independent cohorts. We identified 3 regions with GWS SNPs imputed to the 1000 Genomes reference panel that implicate several biological processes and provide insight into the biology of CAD, including evidence of an inflammatory component in the disorder, which may also mediate risk for SCZ36 and MDD.37,38 The smallest P value observed (P = 4.32 × 10−10) was at rs143244591 in RP11-206M11.7. Little is known about this antisense transcript or which, if any, genes it regulates. Minor alleles were protective. The next most significant locus was SLC35G1 (rs146091982, P = 1.33 × 10−9), a potential member of the drug/metabolite transporter superfamily (EamA, previously DUF6). Ubiquitously expressed, SLC35G1 binds stromal interaction molecule 1, a calcium sensor that communicates the calcium load within the endoplasmic reticulum to store-operated channels in the plasma membrane39 when calcium stores in the endoplasmic reticulum are depleted.40 The SLC35G1–stromal interaction molecule 1 complex
