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Chunk #45 — Discussion

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Multiethnic polygenic risk scores improve risk prediction in diverse populations.
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did not incorporate local ancestry, which could potentially improve prediction accuracy in admixed populations (Seldin, Pasaniuc, & Price, 2011). Seventh, we did not incorporate data from the X chromosome, which is likely to harbor additional heritability that could improve prediction accuracy (Tukiainen et al., 2014). Finally, we focused our analyses on common variants, but future work may wish to consider rare variants as well.