Chunk #9 — Materials and Methods — Genotyping

Source

ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.

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Two additional SNPs not present on the GWAS microarray were genotyped via TaqMan assay: rs1229984 in ADH1B and rs671 in ALDH2. Both SNPs are functional variants encoding alcohol-metabolizing enzymes known to contribute to AD risk in Asian populations. Locations are mapped to NCBI Build 36 throughout.