in allele frequency and LD tagging of causal variants to loss of PRS accuracy with varying ancestry, we do not delineate how each of these factors decreases accuracy independently; this is a direction for future work. Finally, we have only simulated individuals from Yoruba, a West African population, which is not representative of the greater diversity in Sub-Saharan Africa.32 Future studies must be done to ensure our findings can be extended to individuals from other regions of Africa.
