Overall, our findings support the concern that while studies have demonstrated the potential clinical utility of PRSs, adopting the current versions of these scores could contribute to inequality in healthcare.4 Going forward, future studies should prioritize the inclusion of diverse participants, and care must be taken with the interpretation of currently available risk scores. While statistical approaches may offer improvements in accuracy compared to current European-derived risk scores, in order to truly diminish the disparity and achieve PRS accuracies similar to in European ancestry populations we must actively recruit and study diverse populations.
