The P2Y14 receptor is preferentially expressed in hematopoietic stem cells of both humans and mice.308 While physiological functions of this receptor remain to be established, expression of the P2Y14 receptor has been detected in immune cells, suggesting its connotation with inflammation.309 Most of the data on P2Y14 is associated with its peripheral effects, but there are indications of its expression in human astrocytes310 and rat cortical and cerebellar astrocytes.311 Increased P2Y14 receptor expression in LPS-mediated microglial activation also suggests its role in CNS inflammatory responses.312 In mice, P2Y14 deficiency has not shown to carry a noticeable CNS effect under homeostatic conditions, but showed reduced tolerance to glucose and insulin secretion deficiency.313 A variety of factors including aging, radiation therapy, consecutive exposure to chemotherapy, and repeated bone marrow transplantation have shown to increase senescence in animals lacking P2Y14 receptor.314
