Chunk #75 — P2Y Receptors and Functions in the CNS — P2Y13 Receptor and Functions in the CNS

Source

Purinergic Receptors of the Central Nervous System: Biology, PET Ligands, and Their Applications.

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Among the P2Y13 receptor antagonists, there are some nonselective P2Y12/13 antagonist including a highly potent P2Y12 antagonist AR-C69931 (IC50 = 0.4 nM) and 2-MeSAMP.221 However, nonnucleoside MRS-2211 is a selective antagonist of P2Y13 and displays high selectivity over P2Y1 and P2Y12 receptors.307