The A allele of rs1229982 is found at a low frequency (0.2) in European Americans (CEU); it is at high frequency in the Nigeria (YRI) population (60%) but is completely lost in the Asian populations (CHB, JPT). In the European-American population [25], the A allele was observed to be overtransmitted to alcoholics. This is somewhat surprising, given that higher ADH activity coding alleles are protective [13–20].
