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Chunk #12 — 3. Results and Discussion

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Variation in the ADH1B proximal promoter affects expression.
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The ADH1B proximal promoter region extending to 270 bp upstream of the translational start site has binding sites for multiple transcription factors [29–30]. A putative CCAAT enhancer binding protein (C/EBP) family of transcription factor was predicted by PROMO [31] at rs1229982, which might explain the effect on promoter activity.