In conclusion, we identified four putative BMI loci at PP13439-TMEM212, CDH12, MFAP3-GALNT10, and FER1L4 that demonstrated consistent association in six African-American GWAS and replication cohorts. We observed excess association signals in both the GWAS and replication studies, suggest there are additional loci remained to be identified. Given the differences in environment, body composition, and genetic backgrounds among different ethnic groups, additional studies and meta-analyses in African Americans and comparison of results to other ethnic groups is necessary to shed light on whether allelic and locus heterogeneity have a significant contribution to the genetics of adiposity in various ethnic groups.
