The Study of Addiction – Genetics and Environment (SAGE) is a comprehensive GWA study using approximately 4,000 unrelated subjects of European and African-American descent. Cases with AD include 1,944 subjects with the primary phenotype having been DSM-IV AD (Bierut et al., 2010). Controls consist of 1,965 subjects who have used alcohol, but have never been addicted to alcohol or other illicit substances. In order to screen for substance dependence, MaxDrinks were asked to potential control subjects. In the present study, we used 1628 Caucasian individuals with MaxDrinks (629 males and 999 females) from the combined data of the Family Study of Cocaine Dependence (FSCD), and the Collaborative Genetic Study of Nicotine Dependence (COGEND) in the SAGE study. It contains about 1 million Illumina SNPs (1,069,796 SNPs).
