Participants, who were of mixed heritage but at least one-sixteenth Native American, were recruited from eight geographically contiguous reservations with a total population of about 3,000 individuals. They were recruited using a combination of a venue-based method [73,74], and a respondent-driven procedure [75], as described previously [64,76]. To be included in the study a participant had to be an American Indian of one of four tribal groups between the age of 18 and 70 without major medical problems that would preclude mobility.