In conclusion, follow-up of previous independent reports of linkage on chromosome 2 in the COGA sample with alcohol dependence, conduct disorder, and suicide attempts results in a maximal LOD score of 5.4 in the sample with the phenotype of AD with CD or SUI. A systematic screen of SNPs across chromosome 2 with the comorbid AD with CD or SUI phenotype yields evidence of association with 23 genes located across chromosome 2, likely contributing to the preponderance of reported linkages with alcohol dependence and related phenotypes across chromosome 2. These genes may represent novel genes associated with phenotypes resulting from behavioral undercontrol. Confirmation in independent samples will be the next step.
