The hypothesis of a possible multiplicative interaction between risk genotype (AA) and environmental risk (lowest quartile parent monitoring) was tested in Multivariate model 2 (Table 2 left panel). This model showed an interaction between the risk genotype (AA) of rs16969968 and lowest quartile of parent monitoring (p=0.034), controlling for age and gender. Due to the evolutionary relationship between rs16969968 and rs3743078 as detailed in the methods section, we tested this result and the interaction between lowest quartile parent monitoring and risk genotype of rs16969968 (AA) while holding the rs3743078 genotype constant (GG) by conducting the same analyses in subjects with the same genotype for rs3743078 (CC) (14). We found a similar interaction between the risk genotype (AA) of rs16969968 and lowest quartile parent monitoring (p=.009).
