Chunk #53 — Online Methods — Implication of causal genes

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Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.

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lung function traits (or a proxy with r2>0.9) was also the variant most strongly associated with expression of the gene in one or more of the eQTL datasets (i.e. there was co-localisation of the lung function associated SNP and the gene expression associated SNP). Due to extended linkage disequilibrium across the MHC region, only high-priority genes were identified for the signals in the MHC.