The genes implicated for each signal (high-priority genes only and all genes) were tested for enrichment of gene sets and pathways using ConsensusPathDB62. Pathways or gene sets represented entirely by genes implicated by the same association signal were excluded. Pathways or gene sets represented by 2 or more genes from the same association signal were flagged. Pathway enrichment using all genome-wide P values was undertaken using MAGENTA63 as previously described15. Gene sets/pathways with FDR<5% either including the HLA region or excluding the HLA region were reported.
