In order to further explore whether the SNPs identified in the within COGA meta analysis would replicate in S4S, we looked at the association statistics for the S4S specific GWAS. None of the individuals SNPs replicated. Only 3 of the seven lead SNPs had concordant signs across each sample. We would expect 50% of the SNPs to have the same sign by chance, and 5% of lead SNPs to have a p < 0.05, so this also failed replication.
