Chunk #27 — Materials and methods — Clozapine-N-oxide dose response for chemogenetic interventions of neuronal network

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Development of a high-throughput arrayed neural circuitry platform using human induced neurons for drug screening applications.

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In addition to CNO, we also investigated the effects of 500 nM clozapine on the circuit in both hM3Dq-infected cultures and non-infected cultures as a control for CNO stimulation.