having the highest log2FC in both regions. In the ventral striatum, no DE genes were detected at FDR < 0.05. The most significant differential gene expression in the ventral striatum was observed for Ankyrin Repeat And Ubiquitin Domain Containing 1 (ANKUB1) which was upregulated in AUD cases (log2FC = 1.35, p = 5.8 × 10−5). In the VS of AUD cases, Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit B (CLPB, log2FC = −0.11, p = 5.2 × 10−6) was the most significantly downregulated gene.
