Gene expression analysis of postmortem brain tissue from AUD cases and controls revealed DE genes at FDR < 0.05 in both dorsal striatal regions. In the caudate nucleus, 49 DE genes were identified at FDR < 0.05 (39 up- and 10 downregulated). Tubulin Tyrosine Ligase Like 4 (TTLL4, log2FC = 0.11, p = 2.3 × 10−8) and GATA Binding Protein 2 (GATA2, log2FC = −0.27, p = 8.6 × 10−7) were the most significantly upregulated and downregulated genes, respectively. Top up- and downregulated genes in the putamen were found to be Transcription Elongation Factor A Like 2 (TCEAL2, log2FC = 0.09, p = 5.8 × 10−5) and Desmin (DES, log2FC = −0.86, p = 2.6 × 10−6), the latter being the only significant gene after correction for multiple testing. Nine genes were downregulated in both dorsal striatal regions, with HLA-DOB having the highest log2FC in both regions. In the ventral striatum, no DE genes were detected at FDR < 0.05. The most significant differential gene expression in the ventral striatum was observed for Ankyrin Repeat And Ubiquitin Domain Containing 1
