We tested the association between PAU PRS and alcohol dependence in 3 independent samples: the iPSYCH group (ncase = 944, ncontrol = 11,408, neffective = 3,487); University College London (UCL) Psych Array (ncase = 1,698, ncontrol = 1,228, neffective = 2,851); and UCL Core Exome Array (ncase = 637, ncontrol = 9,189, neffective = 2,383). The PAU PRSs were significantly associated with AD in all three samples, with the most variance explained in the UCL Psych Array sample, which includes the most alcohol dependence cases (PTbest = 0.001, R2 = 2.12%, p = 8.64 × 10−14). In the iPSYCH group and UCL Core Exome Array samples, the maximal variance explained was 1.61% (PTbest = 0.3, p = 1.87 × 10−22), and 0.77% (PTbest = 5 × 10−8, p = 1.65 × 10−7), respectively (Supplementary Table 13).
