We calculated PRS for PAU in 67,589 individuals of European descent from the Vanderbilt University Medical Center’s biobank, BioVU. We conducted a phenome-wide association study (PheWAS) of PRS for PAU adjusting for sex, age (calculated as the median age across an individual’s medical record), and the top 10 principal components of ancestry. We standardized the PRS so that the odds ratios correspond to a standard deviation increase in the PRS. After Bonferroni correction, 31 of the 1,372 phenotypes tested were significantly associated with PAU PRS, including alcohol-related disorders (OR = 1.46, se = 0.03, p = 3.34 × 10−40), alcoholism (OR = 1.33, se = 0.03, p = 3.85 × 10−28), tobacco use disorder (OR = 1.21, se = 0.01, p = 2.71 × 10−38), 6 respiratory conditions, and 17 additional psychiatric conditions (Figure 5, Supplementary Table 12).
