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Chunk #9 — Results — Ancestry-specific meta-analyses of TUD.

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Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.
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Again, combining these data with those of UKBB in a secondary GWAS (TUD-EUR+UKBB) yielded very similar results (e.g., similar h2SNP estimate of 9.30% and rg estimate of 0.99, SE=0.001; lead SNPs and independent loci presented in Supplementary Table 12). Considering the similarity between the primary and secondary GWAS, all downstream analyses used the EUR GWAS for the most stringent TUD definition (TUD-EUR), which excluded the UKBB sample.