The TUD-AA meta-analysis yielded a significant h2SNP estimate of 11.09% (SE=0.014, Supplementary Table 9), and 2 independent loci (Supplementary Table 13), one on chr. 9 (rs2007153, p=1.17E-08) in DBH, which is novel for the AA population, and another on chr. 20 (rs6011779, p=9.27E-09) in the CHRNA4 gene, replicating a finding from a prior multi-ancestral (EUR+AA) GWAS of smoking.27 Multi-ancestry fine-mapping analyses using PAINTOR corroborated the region in chr. 9, identifying two potential causal variants in this locus (Supplementary Table 14). The TUD-LA GWAS yielded a significant h2SNP estimate of 8.14% (SE=0.02, Supplementary Table 9) but did not identify any GWS loci (Figure 2), presumably due to the smaller sample size.
