Chunk #11 — Results — Integration of GWAS results with functional genomic data.

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Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.

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To further our biological interpretation of the TUD-EUR GWAS results and prioritize potential candidate genes and proteins, we performed multiple in silico downstream analyses using MAGMA,41,42 H-MAGMA,43 S-MultiXcan/S-PrediXcan,44 TWAS,45 and PWAS.45