Chunk #12 — Results — Integration of GWAS results with functional genomic data.

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Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.

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First, we conducted gene-based analyses via MAGMA,41,42 which mapped SNP-level associations to 91 significant genes (p<2.63E-06), 20 (21.62%) of which replicated genes near or in GWS loci (e.g., CHRNA3, CHRNA4, KDM4A, DBH; Supplementary Table 15).