To identify neurobiologically relevant target genes, we incorporated TUD GWAS data with chromatin interaction profiles from human brain tissue using Hi-C coupled MAGMA (H-MAGMA).43 These analyses identified 1,017 unique gene-tissue pairs associated with TUD (p<9.44E-07), a significant proportion of which showed cell-type (15.63% cortical neurons, 16.42% iPSC-derived neurons, 20.75% midbrain dopaminergic neurons, 14.25% iPSC-derived astrocytes) or developmental stage-specific (15.73% fetal, 17.21% adult) expression (Supplementary Table 16).
