and the prior knowledge that each region harbors a risk variant for BMI. We also looked for novel independent associations, focusing on the genotyped and imputed SNPs that were uncorrelated with the index signal in the initial GWAS populations (r2<0.2). Here, we applied a Bonferroni correction for defining novel associations as significant in each region, as 0.05/the total number of tags needed to capture (r2≥0.8) all common risk alleles across all risk regions in the YRI population (α=6.7×10−6).
