We evaluated the evidence for recent positive selection at our novel loci using several statistical techniques, the BioVU African American GWAS data, and data from the International HapMap Project and the Human Genome Diversity Project (HGDP). We compared adjusted allele frequencies among BioVU, and HapMap phase 3 participants from West African Yoruban (YRI) and East African Luhya (LWK) using Treeselect15. The LWK sample is differentiated from the YRI and samples of African Americans16. Allele frequencies in the African American sample were adjusted by subtracting the expected contribution of European alleles, where pAA is the allele frequency in African Americans obtained from experimental data, pEA is the allele frequency in Europeans obtained from HapMap, pAF is the estimated allele frequency in African founders, and α is the average proportion of ancestry from Europeans, or 0.2. The adjustment is then performed by solving the following expression for pAF.
