In AA families, rs6719226 major allele (C) was transmitted significantly more frequently to offspring with OD than expected (P=0.010, which could withstand the Bonferroni correction at the level of α=0.050/5=0.010). In EA families, rs6713532 minor allele (C) was transmitted more often to offspring with CD than by chance, and a marginally significant association was found between this marker and CD (P=0.044) (Table 3). To examine further the evidence for association of POMC with AD, CD, or OD, haplotype-based analyses including all five markers were performed. However, none of these haplotypes was found to be over transmitted to affected offspring (Supplementary Material Table S1).
