paperKB
coga / coga-kb
Help
Sign in

Chunk #17 — Results — Case-control Association Analysis Results

Source
Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies.
Embedded
yes

Text

Individual marker case-control analysis results are given in Table 4. In AA samples, the frequency of rs6719226 major allele (C) was non-significantly more common in OD cases (72.0%) than in controls (65.0%) (Pallele-wise=0.072). Rs6545976 major allele (G) was significantly more common in OD cases (61.0%) than in controls (51.0%) (Pallele-wise=0.035). The frequency of rs1866146 minor allele (C) was significantly higher in CD and OD cases (13.0% and 16.0%, respectively) as compared to controls (8.0%) (CD vs. Con: Pallele-wise=0.017; OD vs. Con: Pallele-wise=0.010). In EA samples, a nominally-significant association was noted between rs3769671 and CD (Pallele-wise=0.035). Rs6713532 minor allele (C) was significantly more frequent in AD and OD cases (26.0% and 27.0%, respectively) as compared to controls (20.0%) (AD vs. Con: Pallele-wise=0.008; CD vs. Con: Pallele-wise=0.003) (both associations withstood the Bonferroni correction at the level of α=0.050/5=0.010). Similarly, there was an increased frequency of rs1866146 minor allele (C) in AD, CD, and OD cases (35.0%, 39.0%, and 37.0%, respectively) than in controls (28.0%) (AD vs. Con: Pallele-wise=0.002; CD vs. Con: Pallele- wise=0.001; OD vs. Con: Pallele-wise=0.003). The positive association between rs1866146