increased frequency of rs1866146 minor allele (C) in AD, CD, and OD cases (35.0%, 39.0%, and 37.0%, respectively) than in controls (28.0%) (AD vs. Con: Pallele-wise=0.002; CD vs. Con: Pallele- wise=0.001; OD vs. Con: Pallele-wise=0.003). The positive association between rs1866146 and OD in AAs or all three phenotypes in EAs survived a Bonferroni correction (α=0.050/5=0.010). Figure 3 summarizes the association significance (denoted as −log10P-value) of five POMC SNPs in AD, CD, and OD from both family- and case-control-based studies using samples collected from the two populations (AAs and EAs).
