Chunk #211 — VII. Classes of genes that are identified in multiple GWA samples for multiple phenotypes: Focus on cell adhesion related genes

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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We sought possible functional effects of these 5’ NrCAM haplotypes by assessing patterns of allele specific expression of NrCAM haplotypes in mRNAs extracted from human postmortem brains. mRNA corresponding to the addiction-associated 5’ NrCAM haplotype was expressed at an average of 26% of the levels of expression of mRNAs encoded by the alternative haplotypes.