Chunk #212 — VII. Classes of genes that are identified in multiple GWA samples for multiple phenotypes: Focus on cell adhesion related genes

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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When we compared NrCAM mRNA levels in cerebral cortex, midbrain and hippocampal samples from individuals who were heterozygotes for this 5’ NrCAM haplotype to samples from individuals who lacked it, expression was about 40% lower in the brains of individuals who displayed the disease-associated haplotype. None of the adjacent genes’ expression revealed such evidence for haplotype-specific differential expression.