acid changes at this locus was associated with alcoholism in two GWASs candidate gene substudies on people of European descent, but the difference did not reach statistical significance for genome-wide analyses (Kendler et al. 2011; Treutlein et al. 2009). The ADH1C*1 allele has been associated with increased risk for alcohol-related cancer, particularly in people who consume alcohol (Seitz and Meier 2007).
