The judicious addition of GxE research to the behavior genetics armamentarium has the potential to improve understanding of the etiology of problematic alcohol consumption and AUDs. However, this area of research is relatively new and constrained by various methodological and conceptual limitations. A number of researchers have elegantly reviewed these limitations as they relate to the study of GxE across a broad range of phenotypes (Eaves, 2006; Uher, 2008; Wong, Day, Chan, & Wareman, 2003). We focus our discussion on conceptual and methodological limitations as they relate to GxE on alcohol consumption and AUDs and provide recommendations to aid future research.
