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Chunk #79 — 4. Discussion — 4.2. Clinical, electrophysiological and behavioral correlates of odor detection in CHR patients

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Olfaction in the psychosis prodrome: electrophysiological and behavioral measures of odor detection.
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Recent literature reviews indicate that on average about 1/4 to 1/3 of cases included in high-risk studies show a conversion to psychosis within 2–3 years, but there is also a considerable range in transition rates between studies (Gee & Cannon, 2011; Fusar-Poli et al., 2012a; Simon et al., 2011). The incidence rate for transition to psychosis for the current sample falls within these reported ranges (i.e., 3/21 = 14%). Most importantly, the three converters differed substantially from the observed group means in odor thresholds, odor detection, and olfactory ERPs, all indicative of markedly reduced olfactory function, which strongly implies that measures of olfactory function may be a promising endophenotype for schizophrenia and its risk states (Turetsky et al., 2012). However, in contrast to prior studies (i.e., Brewer et al., 2003; Woodberry et al., 2010), the three converters did not show any abnormalities in odor identification, which warrants a more careful review of these results. Relying on the 40-item version of the UPSIT (Doty et al., 1984), Brewer et al. (2003) failed to find SIDs between 59 CHR nonconverters (M =