Pooled epidemiological studies of cardiovascular disease risks show that the RR decreases with age, and that the inverse age association is roughly log-linear. Based on a pooled analysis of several risk factors (high blood pressure, high fasting plasma glucose, high total cholesterol, and tobacco smoking), the age at which the RR reaches 1 is often between 100 and 120 years. We therefore estimated age-specific RRs for all cardiovascular risk factors by meta-regression of available data with logRR as the dependent variable and median age at event as the independent variable with an age intercept (RR=1) at age 110 years. Uncertainty in the RR was generated by simulation analyses.152
