Partitioning heritability of PCL-Total in EUR revealed 1.28-fold to 1.39-fold enrichment of SNPs associated with four GTEx cortical tissue types: cortex, frontal cortex (BA9), anterior cingulate cortex (BA24), and nucleus accumbens (FDR q < 0.05; Supplementary Table 9). Intronic regions had 1.29-fold enrichment (FDR q < 0.05). Cell-type partitioning analyses support SNP-h2 enrichment of the frontal cortex (BA9) gene sets (tau-c = 3.42 × 10−9, P = 0.002) above other annotations in the model, and frontal cortex (BA9), anterior cingulate cortex (BA24), and multiple basal ganglia (putamen, caudate, and nucleus accumbens) gene expression profiles (tau-c ranging from 1.02 × 10−9 to 3.43 × 10−9, FDR q < 0.05), above that of all other genomic annotations. These regions were prioritized when considering transcriptome-wide association results to constrain interpretation of those results to the most pertinent and evidence-driven tissues40.
