PrediXcan-S41 was used to correlate imputed tissue-specific genetically regulated gene expression determined by association with reference transcriptome datasets with PCL-Total results. We observed significant negative correlation with predicted expression of the protein product of the pseudogene LRRC37A4P in amygdala, substantia nigra, putamen, frontal and anterior cingulate cortex, adrenal gland, and whole blood tissues. Also noted were significant positive correlations with predicted expression of CRHR1 in amygdala, hippocampus, frontal and anterior cingulate cortex, adrenal, and whole blood (although negative correlation was seen for nucleus accumbens); significant positive correlation with predicted expression of PLEKHM1, ARL17A, LRRC37A2, and DND1P1 (all of which are co-localized on 17q21.31) in multiple brain regions including amygdala, anterior cingulate cortex, and basal ganglia; and significant negative correlation with predicted expression of RBM6 in frontal cortex, hippocampus, nucleus accumbens, adrenal, and whole blood. The complete list of PrediXcan-S results is available in Supplementary Table 10. The significant genes for 13 brain tissues were then tested for shared causal loci. The coloc method42 reports posterior probability for a pair of traits under the hypothesis (H4) that traits are associated and
