is available in Supplementary Table 10. The significant genes for 13 brain tissues were then tested for shared causal loci. The coloc method42 reports posterior probability for a pair of traits under the hypothesis (H4) that traits are associated and share a single causal variant. The genetically regulated transcriptomic profiles of ARL17A, LRRC37A2, RNF123, FAM212A and PLEKHM1 showed high probability (≥90%) of a shared causal locus (coloc H4) with PCL-Total across multiple brain regions. CRHR1 probability was highest (85%) for hippocampus tissue expression (Supplementary Data 2).
