We identified three large-scale T2D GWAS conducted in different populations to derive a trans-ancestry T2D PRS: (i) a GWAS in individuals of European descent with 74,124 T2D cases and 824,006 controls [8]; (ii) a meta-GWAS of T2D in African Americans performed by the MEta-analysis of type 2 Diabetes in African Americans (MEDIA) Consortium with 8,284 cases and 15,543 controls [22]; and (iii) a GWAS in the Japanese population with 45,383 cases and 132,032 controls, performed by Biobank Japan (BBJ) [23].
