the opportunities and challenges in the clinical translation of T2D PRS. Specifically, we integrated T2D GWAS in European, African, and East Asian individuals to construct the trans-ancestry PRS using state-of-the-art Bayesian polygenic modeling methods [18], and evaluated the PRS in the multi-ethnic eMERGE I-III samples [19], four Black cohorts, and the Taiwan Biobank [20, 21]. We additionally assessed a post hoc ancestry adjustment method that can express the polygenic risk on the same scale across populations and facilitate the use of a single cutoff to identify high-risk individuals with ancestrally diverse backgrounds in prospective cohorts. Our efforts represent the first step towards the implementation of T2D PRS into routine clinical care.
