Chunk #55 — Online Methods — Genome-wide survival association study datasets — (4) Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)
severity equivalent to a CDR of 1 or greater, and had symptoms of dementia for at least 6 months. All individuals identified as having Alzheimer-related dementia met the NINCDS-ADRDA criteria for definite, probable, or possible AD. Vascular Dementia was diagnosed using the ADDTC criteria but the presence of vascular dementia did not disqualify a participant from obtaining a concomitant diagnosis of AD if indicated. The recruitment of Original cohort participants at FHS had occurred long before the DNA collection with the result that the majority of dementia events in the FHS (although ascertained prospectively) were prevalent at the time of DNA collection or these persons had died prior to DNA draw and were thus excluded from analyses of incident disease. Due to the limited number of incident dementia and AD events in the Framingham Offspring only the Original cohort were included in our analyses of incident events.
