Chunk #56 — Online Methods — Genome-wide survival association study datasets — (4) Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)
Rotterdam Study: The Rotterdam Study enrolled inhabitants from a district of Rotterdam (Ommoord) aged ≥55 years (N=7,983, virtually all white) at the baseline examination in 1990–93 when blood was drawn for genotyping63. It aims to examine the determinants of disease and health in the elderly with a focus on neurogeriatric, cardiovascular, bone, and eye disease. All inhabitants of Ommoord aged ≥55 years (n = 10,275) were invited and the participation rate was 78%. All participants gave written informed consent to retrieve information from treating physicians. Baseline measurements were obtained from 1990 to 1993 and consisted of an interview at home and two visits to the research center for physical examination. Survivors have been re-examined three times: in 1993–1995, 1997–1999, and 2002–2004. All persons attending the baseline examination in 1990–93 consented to genotyping and had DNA extracted. This DNA was genotyped using the Illumina Infinium II HumanHap550chip v3·0 ® array in 2007–2008 according to the manufacturer’s protocols. Genotyping was attempted in persons with high-quality extracted DNA (n=6,449). From these 6,449, samples with low call rate (<97.5%, n=209), with excess autosomal heterozygosity
