Our lab and others around the globe are utilizing this technology to ask important questions about neuronal networks. Current neuronal processes being studied with this model include network dynamics, development, learning and memory, synaptic plasticity, excitotoxicity, ischemia and neurodegeneration.3-10 Findings from these studies could have significant implications for establishing better treatments for human diseases like congenital malformations, epilepsy, stroke and Alzheimer's disease. The purpose of this protocol is to provide the necessary information for setting up, caring for, recording from and stimulating cultures on MEAs. The ultimate goal is to provide a means for researchers to ask physiologically relevant questions at the cellular and network levels that may perhaps lead to a better understanding of brain function and dysfunction and ultimately the treatment of diseases that affect our neurons and how they communicate.
